Research

Our focus will be on the development and application of nonlinear optical methods for studying dynamic biophysical and material systems in real time.

Publications (prior to ND)

Kratochvil H.T.; Carr J.K.; Matulef K.; Annen A.W.; Li H., Maj M.; Ostmeyer J.; Serrano A.L.; Raghuraman H.; Moran S.D.; Skinner J.L.; Perozo E.; Roux B.; Valiyaveetil F.I.; Zanni M.T. Instantaneous ion configurations in the K+ ion channel selectivity filter revealed by 2D IR spectroscopy. Science vol 353 p1040

Ostrander J.S.; Serrano A.L.; Ghosh A; Zanni M.T. Spatially Resolved Two-Dimensional Infrared Spectroscopy via Wide-Field Microscopy. ACS Photonics 2016 3, 1315-1326.

Serrano A.L.†; Ghosh A.†; Oudenhoven T.A.; Ostrander J.S.; Eklund E.C.; Blair A.F.; Zanni M.T. Experimental implementations of 2D IR spectroscopy through a horizontal pulse shaper design and a focal plane array detector. Optics Letters 2016 41, 524-527.

Serrano A.L.†; Ghosh A.†; Ostrander J.S.; Zanni M.T. Wide-Field FT-IR Microscopy using Mid-IR pulse-shaping. Optics Express 2015 23, 17815-17827.

Ghosh A.; Ho J.J.; Serrano A.L.; Skoff D.R.; Zhang T.O.; Zanni M.T. Two-dimensional sum-frequency generation (2D SFG) spectroscopy: summary of principles and its application to amyloid fiber monolayers. Faraday Discuss 2015 117, 493-505.

Tu L.H.; Serrano A.L.; Zanni M.T.; Raleigh D.P. Mutational Analysis of Preamyloid Intermediates: The Role of His-Tyr Interactions in Islet Amyloid Formation. Biophysical Journal 2014 7, 1520.

Laaser J.E.; Skoff D.R.; Ho J.J.; Joo Y.; Serrano A.L.; Steinkruger J.; Gopalan P.; Gellman S.H.; Zanni M.T. Two-dimensional sum-frequency generation (2D SFG) reveals structure and dynamics of a surface-bound peptide. Journal of the American Chemical Society 2014 136, 956.

Serrano, A.L.; Bilsel O.; Gai, F. Native State Conformational Heterogeneity of HP35 Revealed by Time-Resolved FRET. Journal of Physical Chemistry B 2012 116, 10631-10638.

Serrano, A.L.; Waegele, M.M.; Gai, F. Spectroscopic Studies of Protein Folding: Linear and Nonlinear Methods.* Protein Science 2012 21, 157-170.

Serrano, A.L.†;Culik, R.M.†; Bunagan, M.R.; Gai, F. Achieving Secondary Structural Resolution in Kinetic Measurements of Protein Folding: A Case Study of the Folding Mechanism of Trp-Cage. Angewandte Chemie-International Edition 2011 50, 10884-10887.

Serrano, A.L.; Tucker, M.J.; Gai, F. Direct Assessment of the Alpha-Helix Nucleation Time. Journal of Physical Chemistry B 2011, 115, 7472-7478.

Urbanek, D.C.; Vorobyev, D.Y.; Serrano, A.L.; Gai, F.; Hochstrasser, R. M. The Two-Dimensional Vibrational Echo of a Nitrile Probe of the Villin HP35 Protein. Journal of Physical Chemistry Letters 2010 1, 3311-3315.

Serrano, A.L.; Troxler, T.; Tucker, M.J.; Gai, F. Photophysics of a Fluorescent Non-Natural Amino Acid: P-Cyanophenylalanine. Chemical Physics Letters 2010 487, 303-306.

Ma, Y.; Chiu, P.L.; Serrano, A.L.; Ali, S.R.; Chen, A.M.; He, H. The Electronic Role of DNA-Functionalized Carbon Nanotubes: Efficacy for in Situ Polymerization of Conducting Polymer Nanocomposites. Journal of the American Chemical Society 2008 130, 7921-7928.

(†=equal contributions)